Regeneration Globes are globes that drop when minions and mercenaries are killed. When picked up, they help in replenishing a portion of a hero's health and mana (if they use it).
Globes only last for a short amount of time (six seconds) before disappearing.
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(Patch September 13, 2016) Note: Time before Globes despawn reduced from 8 to 6 seconds.